Immunotherapy is based on cytokines (IL-1, IL-2, FNO, CSF, IFN)

The immune system is regulated by cytokines. They are included into three groups: interleukins, interferons and colony stimulating agents. This review is dedicated to the analysis of their biology and functions from the point of view of the application in clinical practice. In most, the role of this proteins is contradictory, variety and duplicated in a tumour microenvironment. It results in development of the wide spectrum of immune therapeutic strategies in malignancies. A basic problem is absence of the predictive biomarker for the selection of the patients. To select the most effective therapy the perspective methods of the treatment decisions are discussed in this article.