20 years of targeting therapy of solid tumors. successes and failures
Authors: A.A. Tryakin, M.Yu. Fedyanin, I.A. Pokataev
DOI: https://www.doi.org/10.31917/1903183
This article critically reviews twenty years’ experience of targeted therapy use for the treatment of solid tumors. Resistance mechanisms, predictive biomarkers and inter-tumor differences in targeted therapy efficacy are discussed. Data for pros and cons of the use of modern multigene panels in routine practice to personify therapy are critically reviewed.