Percutaneous energy-based tumor ablation: principles, technologies, results



Percutaneous energy-based ablation is a promising minimally invasive treatment of unresectable primary and metastatic tumors of different localizations. This article analyzes the basic principles of the interventions, as well as existing technologies that used for hyperthermic (laser, ultrasound, radiofrequency and microwave ablation), hypothermic (cryoablation) and non-thermal (photodynamic ablation, irreversible electroporation) tumor ablation. The authors discussed the mechanisms of the impact of various types of energy to the tissue, and the advantages and disadvantages of their clinical use. The longterm results of treatment of tumors of the liver, kidney, lung and tumors of other localizations were analyzed in the article. The authors considered the modern ideas of the impact of different types of ablation on the immune system, as well as the potential use of ablative technologies in combination with various methods of cancer immunotherapy.