The germ cell tumors are the most common cancer in men aged 24–35 years and represent a heterogeneous group of neoplasms that frequently occurs in the gonads, mediastinum and retroperitoneum. Their cause has not been fully elucidated but differences in incidences suggest that combination of genetic, epigenetic and environment factors are involved. Testicular germ cell tumors are highly sensitive to chemotherapy and radiotherapy and therefore a curable disease in most of the patients. We present here our own treatment results of germ cell tumor patients. We also summarize the consensus on how to treat germ cell tumors and focus on late toxicity of treatment and quality of life for survivors.