Immunity and cancer
Authors: Z.G. Kadagidze, A.I. Chertkova
Relationship between tumor and immune system is mediated by balance between immune activation and suppression. The dual character of interaction between immune system and tumors currently viewed as a dynamic process of cancer immunoediting. A different population of cells of innate and adaptive immunity: NK-, T-, NKT-cells, macrophages and dendritic cells display a value for anti-tumor immune response. These are heterogenic populations of cells with immunosuppressive and anti-tumor activities. Herein, we characterize main population of immunocompetent cells, effectors and suppressors, as well as their role in the anti-tumor immune response.