Immunity and cancer



Relationship between tumor and immune system is mediated by balance between immune activation and suppression. The dual character of interaction between immune system and tumors currently viewed as a dynamic process of cancer immunoediting. A different population of cells of innate and adaptive immunity: NK-, T-, NKT-cells, macrophages and dendritic cells display a value for anti-tumor immune response. These are heterogenic populations of cells with immunosuppressive and anti-tumor activities. Herein, we characterize main population of immunocompetent cells, effectors and suppressors, as well as their role in the anti-tumor immune response.