Immunologic aspects of tumor biology



This paper represents the review of current perceptions on the biologic mechanisms of tumor development in the context of interplay with host immune system. Various immune factors which impact carcinogenic process in either anti-oncogenic or prooncogenic way are discussed. Also the evolution of the perceptions on the interactions between tumors and immune system from the immune surveillance to immunoediting theory and their principles is described. Additionally insight into phenotypic features of cancers, which determine the choice of various potential immunotherapeutic approaches for tumor treatment is provided.