The journal «Practical oncology»ТОМ 17, №2, 2016, Cancer immunotherapy

Cell-based anticancer immunotherapy methods



Taking into consideration the major role of cellular immunity in tumor rejection mechanisms it is very logical to use ex vivo expanded immune cells for anti-cancer therapy. Adoptive immunotherapy employs several types of cells: dendritic cells, natural killers, LAK, T-lymphocytes. Also novel genetically engineered Т-cell approaches using T-cell receptor and chimeric antigen receptor transfection are studied. This paper reviews current knowledge on the principles of adoptive cellular immunotherapy for cancer and the most notable clinical trials results.