MOLECULAR BIOLOGICAL ASPECTS IN PREDICTING THE LONG-TERM RESULTS OF SURGICAL TREATMENT FOR LOCALLY ADVANCED COLORECTAL CANCER IN PATIENTS OF OLDER AGE GROUPS
Authors: G.M. Manikhas, N.A. Maistrenko, A.A. SazonovAbstract:
Aim. To assess the significance of immunohistochemical diagnostics in determining the molecular biological properties of tumors and predicting the results of surgical treatment in patients with locally advanced colon cancer of older age groups.
Material and methods. The results of surgical treatment of locally advanced colorectal cancer in patients of different age groups were evaluated. The clinical significance of immunohistochemical markers for predicting long-term results was studied.
Results. The most significant risk factors for postoperative complications were identified. The prognostic significance of such immunohistochemical markers as: the index of proliferative activity of cancer stem cells (ALDH+Ki-67+) and the receptor for chemokines CXCR4 was established.
Conclusion. The use of immunohistochemical diagnostics provides additional information about the potential of tumor malignancy, which is necessary for a reasonable choice of surgical tactics.