Colorect al molecular subtypes – progress or deadlock ?
Authors: M.Yu. Fedyanin, E.O. Ignatova, А.А. Tryakin
Attempts to classify tumors in order to substantiate the different course of the disease and response to therapy have undergone significant changes over the past decades and have advanced from the creation of prognostic systems based on the clinical and morphological picture to the division into molecular-genetic subtypes. The latter, based on various omics data, should have opened a new era in oncology, dividing tumors not only according to the prognostic course, but also allowing individualized treatment. However, data from clinical trials, at least in colorectal cancer, show conflicting results. This review is devoted to the critical analysis of the applicability of molecular genetic subtyping of colon tumors in clinical practice.