The journal «Practical oncology» / Т. 20, №1, 2019, The most important events in Oncology in 2018

MOLECULAR-ORIENTED AND PRECISION CANCER THERAPY – THE PRESENT AND FUTURE ASPECTS

Authors: 

DOI: https://www.doi.org/10.31917/2001029
Abstract:

Molecular-oriented cancer therapy implies the use of antitumor drugs made to
interact with preset molecular targets which play an important (key) role in the onset
and development of tumors. In accordance with this strategy the drug is prescribed to
a patient with an appropriate tumor containing a suitable target. Precision therapy
is based on the results of sequencing the patient’s tumor DNA. Thus the spectrum
of molecular targets in this particular tumor can be identified, and the drug can be
selected accordingly irrespective of a tumor type (tumor-type agnostic therapy). The
present-day state of molecular-oriented and precision therapy was analyzed, and the
prospects of its use for raising the efficacy of therapy in routine clinical practice were
considered.

Download