Neoadjuvant and adjuvant radiotherapy: historical and practical aspects



Combination of surgery and radiotherapy is the optimal tactic for many patients with malignant neoplasms, both localized and locally advanced, allowing to achieve the highest rates of local control and survival. The effectiveness of neoadjuvant and adjuvant radiation therapy can only be ensured with a clear understanding of the place and significance of each treatment option, based on the principles of evidence-based medicine. This review will present the historical and most current aspects of radiation therapy as part of combined treatment, and evaluate the advantages of preoperative or postoperative irradiation for tumors of various locations.