Cancer evolution as a new target of treatment paradigm



In clinical practice, the cancer treatment is certainly resulted from the biology of tumor growth, the modern understanding of which is based on the theory of genetic changes. In this regard, the effective strategy is the research and target on trigger mutations in the tumor. Obviously, a malignant neoplasm is the set of the different populations of epithelial, stromal and immune cells as well as intercellular matrix with dynamically changing blood flow, nutrients, acid-base state and oxygen concentration, which is almost not taken into account by clinicians.