Acute Liver Failure: Mechanisms and Management Approaches

A narrative review, written in lecture form and addressed to intensivists working
in oncological institutions, is devoted to the analysis of modern approaches to the
treatment of patients with acute liver failure based on the pathogenesis of this life-
threatening complication. Particular attention is paid to the evolution of tactics for
managing such patients from the point of view of both general therapy priorities and
many of its particular aspects – hemodynamics and hemostasis control, metabolic
pharmacotherapy, nutrition, efferent detoxification technologies. The reader’s
attention is drawn to fundamental difference between new approaches from outdated
ones.