Therapeutic targets of the tumor metabolism
Authors: V.A. Chubenko
Tumor cell metabolism has certain distinctive features such as aerobic glycolysis, utilization of alternative energy sources, increased lipid synthesis, mitochondrial dysfunction, macropinocytosis, autophagy, high levels of ROS, tumor microenvironment and hypoxia. This heterogeneity is determined by the malignant phenotype and the environmental conditions. Targeting specific metabolic pathways may be a promising treatment to increase the overall survival. This paper demonstrates the metabolic reprogramming as the potential anticancer strategy.