The effect of auxiliary drugs on photodynamic cytolysis in photodynamic therapy
Authors: Е.В. Miroshnikova, L.V. Galebskaya, V.A. Dadali, Y.V. Dadali, B.I. Miroshnikov
The effect of pyridine-containing and phenolic compounds (Mexidol, Emoxypine, Vitamin В6, Paracetamol, Propofol, Coenzyme Q10) and imidazole-containing Dexdor on photoinduced hemolysis in PDT was studied in an experiment (on erythrocytes of healthy people’s blood). It was found that Mexidol and Emoxypine showed themselves not as antioxidants, but as powerful agents to enhance the hemolytic effect, while in the area of small doses they showed a membrane- protective antihemolytic effect. Therefore, the possibility of their use as concomitant drugs in PDT is problematic and additional clinical studies are required. The anesthetic Dexdor (dexmedetomidine) did not have a noticeable effect on the rate of hemolysis, which makes it possible to recommend it as a priority drug for drug support of PDT. Sedative Propofol (2,4-diisopropylphenol) and Paracetamol (p-acetoaminophenol) as most phenolic compounds caused significant inhibition of hemolysis, which makes their use in PDT problematic. Coenzyme Q10 (its reduced form – ubiquinol) showed a pronounced inhibitory effect on the hemolysis process, however, it can be recommended as an effective membrane-protective drug to protect the membranes of healthy cells.