Possibilities of cytostatics, hormonal and targeted therapy for operable tumors

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DOI:  https://www.doi.org/10.31917/2404326

Over the past decades, with introduction of the adjuvant drug therapy strategy aimed to eliminating micrometastases after radical surgical treatment, it has been possible to increase he proportion of cured patients with various solid diseases. The article is devoted to a brief review of the use of drugs with adjuvant purpose in models of treatment of breast cancer and non-small cell lung cancer as the most socially significant of malignant neoplasms. Based on clinical studies on drug adjuvant treatment, the role of cytostatic agents, hormonal and targeted drugs in terms of toxicity and expected benefit from improved selection of patient groups was analyzed. The issues of adjuvant drug therapy are discussed, depending on the beginning of treatment, its duration and the sequence of drug prescription. Possible mechanisms for the development of resistance to targeted drugs and predictable ways to overcome it are described.