Hormone replacement therapy in patients with a history of cancer

Primary gonadal insufficiency is a recognized late effect in patients with an oncological history. Hormone deficiency affects the quality of life, cardiometabolic and psychological health with a further increase in morbidity and mortality, increases the risks of sexual dysfunction and infertility. The expansion of the indications for hormone replacement therapy (HRT) is a point to be discussed. Most of the existing clinical guidelines contain chapters on HRT, however, it is not clearin the context of young women with premature ovarian failure or men with testicular insufficiency due to cancer or its treatment. In this review we tried to systematize the available data for the most common oncological diseases, depending on the possibilities of using HRT for men and women.