Introduction. Liver cancer ranks sixth in the structure of cancer incidence and fourth in the structure of cancer mortality in the world. Hepatitis B and C viruses, alcohol, non-alcoholic fatty liver disease (NAFLD) play the leading role in the development of hepatocellular carcinoma (HCC). Diabetes mellitus, alcohol consumption, invasion/thrombosis of the main intrahepatic vessels and portal vein, AFP level, general status, initial symptoms, Child-Pugh cirrhosis class, tumor size have a negative impact on overall survival in patients with HCC.

The aim of our study was to evaluate the influence of various factors, including etiological ones, on the overall survival
of patients with HCC.

Materials and methods. 342 patients with HCC who were put on the regional cancer registry from 2015 to 2021 and
underwent examination and treatment at the Sverdlovsk Regional Oncology Center were included in the study. Of these:
225 men, 117 women. The mean age was 62,5 years. The main etiological factor was viral hepatitis – 177 patients (51,8%),
alcohol – 34 (9,9%), NAFLD – 91 (26,6%), other causes – 40 (11,7%). Median OS was 16,7±1,8 months. In patients with liver
cirrhosis, the median OS for Child-Pugh class A was 23,2 months, B – 4,8 months, C – 1,9 months. Patients with ECOG ≥2,
AFP ≥100 ng/ml had the worst prognosis. Body mass index had no effect on overall survival.

Findings. The main etiological factor in the development of HCC is viral hepatitis, the second most common is NAFLD.
The class of liver cirrhosis, the ECOG status of the patient, high level of AFP, but not the mass index, have prognostic
significance.