PROGNOSTIC SIGNIFICANCE OF STEM CELLS TUMORS AND ALK EXPRESSION IN PATIENTS WITH PRIMARY SKINMELANOMA
Authors: K.S. Titov, M.A. Baryshnikova, A.M. Kazakov, D.A. Khochenkov, E.P. Larionova, D.A. Ryabchikov
Melanoma is the most malignant and aggressive skin tumor. Cancer stem cells (CSCs) can be one of the causes of low sensitivity of skin melanoma to chemotherapy, a short therapeutic effect and the development of resistance to targeted therapy, as well as the lack of effect of immunotherapy with inhibitors of control points of the immune system. Great importance is attached to the role of CSCs in the recurrence of the disease. CSCs is also susceptible to various mutations, but often it does not identify driver mutations characteristic of melanoma (BRAF, MEK, RAS, etc.), this phenomenon requires the search for new targets for targeted therapy, one of which can be Anaplastic lymphoma kinase (ALK).